
S P R A V A T O
What is Spravato?
Spravato (Esketamine) is the first prescription
nasal spray taken with an oral antidepressant
for Treatment Resistant Depression (TRD)
and Major Depressive Disorder (MDD).
Is Spravato covered under
my insurance plan?
Yes. Since Spravato (Esketamine) is an
FDA approved medication, unlike other
Ketamine products, Spravato is covered by
most insurances for TRD and MDD.
What is REMS and
Why is it important?
REMS is short for Risk Evaluation and
Mitigation Strategy. Spravato use is guided
by the REMS program to ensure safety.
Clients must meet specific criteria to
become a candidate. This includes failing
2 previous antidepressants.
What is the route of
administration?
Spravato is administered intranasally.
How long will I need
to be monitored?
There is a minimum of 2 hours of observation
and monitoring of blood pressure at an approved
facility. This is mandated by the FDA .
How often do I need Spravato?
Spravato is delivered in 3 phases and
they are administered as follows:
Phase 1: Induction
(Week 1-4)
Twice Weekly
Phase 2: Maintenance
(Week 5-8)
Once Weekly
Phase 3: Ongoing Treatment
(Week 9+)
Once Every Two Weeks
What are the possible
side effects of Spravato?
Fatigue
Mild Disassociation
Elevated Blood Pressure
Difficulty concentrating and dizziness
Inability to drive or operate machinery
Suicidal thoughts for young adults
Is Spravato right for me?
A comprehensive screening will determine
if you are a good candidate for Spravato.
Referral from a medical provider is required
to ensure the REMS patient criteria is met
prior to starting the Spravato medication.